The article

“Up-Regulation of HMGB1 Exacerbates Renal Ischemia-Reperfusion Injury by Stimulating Inflammatory and Immune Responses through the TLR4 Signaling Pathway in Mice”
[Cell Physiol Biochem 2017;41:2447-2460. DOI: 10.1159/000475914]
by Chuan-Bao Chen, Long-Shan Liu, Jian Zhou, Xiao-Ping Wang, Ming Han, Xing-Yuan Jiao, Xiao-Shun He and Xiao-Peng Yuan

has been retracted by the current and former Publisher and the Editor.

Following publication, concerns were raised about image duplication within Figure 4A. When asked to comment, the authors stated that the raw data underlying this figure has been lost. The authors provided the available original data for the article on request. A review of this data found 2 discrepancies between the data and the findings presented in the article. The authors could not account for these discrepancies with any certainty. As the concerns raised can not be addressed and further concerns were identified in the available data underlying the article, the reliability of the findings presented in the article can not be guaranteed and the article is being retracted.
The authors agree with this retraction.